Anatomical basis of tolerance and immunity to intestinal antigens

被引：975

作者：

Mowat, AM ^{[1
]}

机构：

[1] Western Infirm & Associated Hosp, Dept Bacteriol & Immunol, Glasgow G11 6NT, Lanark, Scotland

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 04期

关键词：

D O I：

10.1038/nri1057

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The intestinal immune system has to discriminate between harmful and beneficial antigens. Although strong protective immunity is essential to prevent invasion by pathogens, equivalent responses against dietary proteins or commensal bacteria can lead to chronic disease. These responses are normally prevented by a complex interplay of regulatory mechanisms. This article reviews the unique aspects of the local microenvironment of the intestinal immune system and discuss how these promote the development of regulatory responses that ensure the maintenance of homeostasis in the gut.

引用

页码：331 / 341

页数：11

共 105 条

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