Diversity-oriented synthesis of polyketide natural products via iterative chemo- and stereoselective functionalization of polyenoates: Development of a unified approach for the C(1-19) segments of lituarines A-C

被引：27

作者：

Smith, AB ^{[1
]}

Walsh, SP

Frohn, M

Duffey, MO

机构：

[1] Univ Penn, Monell Chem Senses Ctr, Dept Chem, Philadelphia, PA 19104 USA

[2] Univ Penn, Res Struct Matter Lab, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 01期

关键词：

D O I：

10.1021/ol047792c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A unified, stereocontrolled synthesis of the C(1-19) segments of the lituarines A-C (1-3) has been achieved, highlighted by application of an iterative chemo- and stereoselective trienoate functionalization protocol, a strategy that holds considerable promise for the diversity oriented synthesis of polyketides.

引用

页码：139 / 142

页数：4

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