The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis

被引：87

作者：

Zaragoza, C

Ocampo, C

Saura, M

Leppo, M

Wei, XQ

Quick, R

Moncada, S

Liew, FY

Lowenstein, CJ

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21205 USA

[2] Univ Coll, Wolfson Inst Biomed Res, London, England

[3] Univ Glasgow, Dept Immunol, Glasgow, Lanark, Scotland

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 05期

关键词：

nitric oxide;

D O I：

10.1073/pnas.95.5.2469

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The host response to Coxsackievirus infection is complex, including T lymphocytes, B lymphocytes, natural killer cells, and macrophages. Although Coxsackievirus infection induces expression of inducible nitric oxide synthase (NOS2; EC 1.14.13.39) in macrophages, the precise role of NOS2 in the host response to Coxsackievirus myocarditis has been unclear. We show, by using mice homozygous for a disrupted NOS2 allele, that Coxsackievirus replicates to higher titers in NOS2(-/-) mice, that the host lacking NOS2 clears virus more slowly than the wild-type host, and that myocarditis is much more severe in infected NOS2(-/-) mice. These data show that NOS2 is crucial for the host response to Coxsackievirus in the mouse.

引用

页码：2469 / 2474

页数：6

共 58 条

[1] Pathogenesis of influenza virus-induced pneumonia: Involvement of both nitric oxide and oxygen radicals [J].