Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene

被引：145

作者：

Honkakoski, P ^{[1
]}

Moore, R ^{[1
]}

Washburn, KA ^{[1
]}

Negishi, M ^{[1
]}

机构：

[1] NIEHS, Pharmacogenet Sect, Reprod & Dev Toxicol Lab, NIH, Res Triangle Pk, NC 27709 USA

来源：

MOLECULAR PHARMACOLOGY | 1998年 / 53卷 / 04期

关键词：

D O I：

10.1124/mol.53.4.597

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

By extending previous studies of the phenobarbital (PB)-responsive 132-base pair (bp) enhancer sequence in the CYP2B10 gene, we have delimited a 51-bp enhancer element that is fully inducible by PB in mouse primary hepatocytes. Sixteen structurally unrelated phenobarbital-type inducers activated the 51-bp enhancer element in transient transfection assays. The results thus indicate that most PB-type inducers, if not all inducers, increase the transcription of the CYP2B10 gene by activating this 51-bp element, now designated PB-responsive enhancer module or PBREM.

引用

页码：597 / 601

页数：5

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