Cardiotoxic transplacental effect of idarubicin administered during the second trimester of pregnancy

被引：42

作者：

Achtari, C ^{[1
]}

Hohlfeld, P ^{[1
]}

机构：

[1] CHU Vaudois, Serv Gynecol & Obstet, CH-1011 Lausanne, Switzerland

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2000年 / 183卷 / 02期

关键词：

acute leukemia; idarubicin; pregnancy;

D O I：

10.1067/mob.2000.105964

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Polychemotherapy including idarubicin was administered during the second trimester to treat acute lymphoblastic leukemia. The infant delivered at 28 weeks' gestation had acute cardiac failure attributed to the cardiotoxic effect of idarubicin. Cardiotoxicity may be caused by idarubicin's biophysical properties that facilitate its transplacental passage. Idarubicin should be used with extreme caution during pregnancy.

引用

页码：511 / 512

页数：2