Disorders of Hemostasis Associated with Chronic Kidney Disease

被引：190

作者：

Jalal, Diana I.

Chonchol, Michel ^{[1
]}

Targher, Giovanni ^{[2
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Div Renal Dis & Hypertens, Denver, CO 80262 USA

[2] Univ Verona, Dept Biomed & Surg Sci, Endocrinol Sect, I-37100 Verona, Italy

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2010年 / 36卷 / 01期

关键词：

Chronic kidney disease; thrombosis; bleeding; hemostatic disorders; CHRONIC-RENAL-FAILURE; GLYCOPROTEIN-IIB-IIIA; CARDIOVASCULAR-DISEASE; PLATELET DYSFUNCTION; TISSUE FACTOR; RISK-FACTORS; MAINTENANCE HEMODIALYSIS; CONSERVATIVE TREATMENT; PLASMINOGEN-ACTIVATOR; DIABETIC-NEPHROPATHY;

D O I：

10.1055/s-0030-1248722

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Chronic kidney disease (CKD) is a growing global health problem. CKD is typically associated with a prothrombotic tendency in the early stages of the disease, whereas in its more advanced stage, that is, end-stage renal disease, patients suffer from a prothrombotic tendency and, in many cases, a bleeding diathesis. The exact etiology behind the coexistence of these conflicting hemostatic disorders is poorly understood. This review critically appraises studies examining the abnormalities in the hemostasis pathway in patients with CKD, as well as the therapeutic options that are currently available to treat these individuals.

引用

页码：34 / 40

页数：7

共 54 条

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Markers of endothelial dysfunction and inflammation in type 1 diabetic patients with or without diabetic nephropathy followed for 10 years - Association with mortality and decline of glomerular filtration rate [J].