Low molecular weight heparin-induced skin necrosis occurring distant from injection sites and without thrombocytopenia

被引：18

作者：

Tietge, UJF ^{[1
]}

Schmidt, HHJ ^{[1
]}

Jäckel, E ^{[1
]}

Trautwein, C ^{[1
]}

Manns, MP ^{[1
]}

机构：

[1] Med Hsch Hannover, Dept Gastroenterol & Hepatol, D-30623 Hannover, Germany

来源：

JOURNAL OF INTERNAL MEDICINE | 1998年 / 243卷 / 04期

关键词：

heparin; skin; necrosis; side effects;

D O I：

10.1046/j.1365-2796.1998.00304.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this paper we report a case of 76-year-old white male patient with skin necrosis induced by subcutaneous prophylactic administration of low-molecular-weight heparin (LMWH). Skin necrosis occured distant from heparin injection sites and without concomitant thrombocytopenia. This is the first reported case presenting these clinical findings.

引用

页码：313 / 315

页数：3

共 14 条

[1] HEPARIN-INDUCED THROMBOCYTOPENIA AND THROMBOSIS [J].

ASTER, RH .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (20) :1374-1376

[2]

BALESTRA B, 1994, EUR J HAEMATOL, V53, P61

[3] HEPARIN-INDUCED THROMBOCYTOPENIA AND THROMBOSIS - CLINICAL AND LABORATORY STUDIES [J].

BOSHKOV, LK ;

WARKENTIN, TE ;

HAYWARD, CPM ;

ANDREW, M ;

KELTON, JG .

BRITISH JOURNAL OF HAEMATOLOGY, 1993, 84 (02) :322-328

[4]

HIRSH J, 1992, BLOOD, V79, P1

[5] HEPARIN-ASSOCIATED THROMBOCYTOPENIA [J].

KING, DJ ;

KELTON, JG .

ANNALS OF INTERNAL MEDICINE, 1984, 100 (04) :535-540

[6] SEVERE SKIN NECROSIS ASSOCIATED WITH HEPARIN IN HEMODIALYSIS [J].

LEBLANC, M ;

ROY, LF ;

LEGAULT, L ;

DUFRESNE, LR ;

MORIN, C ;

THUOT, C .

NEPHRON, 1994, 68 (01) :133-137

[7] SKIN NECROSIS WITH A LOW-MOLECULAR-WEIGHT HEPARIN [J].

OJEDA, E ;

PEREZ, MD ;

MATAIX, R ;

ARBELO, A ;

JIMENEZ, S ;

CAMPO, C ;

BALDA, I .

BRITISH JOURNAL OF HAEMATOLOGY, 1992, 82 (03) :620-620

[8] HEPARIN - ADVERSE REACTION [J].

OTOOLE, RD .

ANNALS OF INTERNAL MEDICINE, 1973, 79 (05) :759-759

[9] SKIN NECROSIS AFTER SUBCUTANEOUS LOW-MOLECULAR-WEIGHT HEPARIN INJECTION [J].

REAL, E ;

GRAU, E ;

RUBIO, M ;

TORRECILLA, T .

AMERICAN JOURNAL OF HEMATOLOGY, 1995, 49 (03) :253-254

[10] Coumarin-induced skin necrosis following heparin-induced thrombocytopenia and thrombosis - A case report [J].

Shahak, A ;

Posan, E ;

Szucs, G ;

Rigo, J ;

Boda, Z .

ANGIOLOGY, 1996, 47 (07) :725-727

← 1 2 →