Analogues of neuropeptide Y containing β-aminocyclopropane carboxylic acids are the shortest linear peptides that are selective for the Y1 receptor

被引：73

作者：

Koglin, N

Zorn, C

Beumer, R

Cabrele, C

Bubert, C

Sewald, N

Reiser, O

Beck-Sickinger, AG

机构：

[1] Univ Regensburg, Inst Organ Chem, D-93040 Regensburg, Germany

[2] Univ Leipzig, Inst Biochem, D-04103 Leipzig, Germany

[3] Univ Bielefeld, Inst Organ & Bioorgan Chem, D-33501 Bielefeld, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 02期

关键词：

amino acids; peptides; peptidomimetics; small ring systems; structure-activity relationships;

D O I：

10.1002/anie.200390078

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Unique, conformationally restricted β-amino acids are a constituent of truncated linear peptides such as 1, which have been obtained for the first time; these species show high and selective affinity toward the Y1 receptor. The high affinity of these ligands is dependent on the position and the configuration of this β-aminocyclopropane carboxylic acid.

引用

收藏

页码：202 / +

页数：5

相关论文

共 13 条

[1] The synthesis of diastereo- and enantiomerically pure β-aminocyclopropanecarboxylic acids [J].

Beumer, R ;

Bubert, C ;

Cabrele, C ;

Vielhauer, O ;

Pietzsch, M ;

Reiser, O .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (26) :8960-8969

[2]

Bubert C, 1997, SYNLETT, P827

[3]

Cabrele C, 2000, J PEPT SCI, V6, P97, DOI 10.1002/(SICI)1099-1387(200003)6:3<97::AID-PSC236>3.0.CO

[4]

2-E

[5] The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats [J].

Cabrele, C ;

Langer, M ;

Bader, R ;

Wieland, HA ;

Doods, HN ;

Zerbe, O ;

Beck-Sickinger, AG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (46) :36043-36048

[6] [LEU31,PRO34]NEUROPEPTIDE-Y - A SPECIFIC Y-1 RECEPTOR AGONIST [J].

FUHLENDORFF, J ;

GETHER, U ;

AAKERLUND, L ;

LANGELANDJOHANSEN, N ;

THOGERSEN, H ;

MELBERG, SG ;

OLSEN, UB ;

THASTRUP, O ;

SCHWARTZ, TW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (01) :182-186

[7] A receptor subtype involved in neuropeptide-Y-induced food intake [J].

Gerald, C ;

Walker, MW ;

Criscione, L ;

Gustafson, EL ;

BatzlHartmann, C ;

Smith, KE ;

Vaysse, P ;

Durkin, MM ;

Laz, TM ;

Linemeyer, DL ;

Schaffhauser, AO ;

Whitebread, S ;

Hofbauer, KG ;

Taber, RI ;

Branchek, TA ;

Weinshank, RL .

NATURE, 1996, 382 (6587) :168-171

[8] Neuropeptide Y feeding receptors: are multiple subtypes involved? [J].

Inui, A .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (02) :43-46

[9]

Khiat A, 1998, J PEPT RES, V51, P317

[10] Synthesis of Fmoc-β-homoamino acids by ultrasound-promoted Wolff rearrangement [J].

Müller, A ;

Vogt, C ;

Sewald, N .

SYNTHESIS-STUTTGART, 1998, (06) :837-841