Transcriptional regulation by cAMP in the heart

被引：40

作者：

Müller, FU ^{[1
]}

Neumann, J ^{[1
]}

Schmitz, W ^{[1
]}

机构：

[1] Univ Munster, Inst Pharmakol & Toxikol, D-48149 Munster, Germany

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2000年 / 212卷 / 1-2期

关键词：

heart failure; adrenergic receptor; beta-adrenoceptor antagonist; cAMP-response element (CRE); cAMP-response element binding protein (CREB); cAMP-response element modular (CREM);

D O I：

10.1023/A:1007176030884

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stimulation of the cAMP-dependent signalling pathway by beta -adrenergic catecholamines is an important physiological mechanism to increase contractile force in the heart. In addition to this, long-term beta -adrenergic stimulation by elevated catecholamines also influences the expressional control of functionally relevant cardiac regulatory proteins in human heart failure. The regulation of transcription by the cAMP-response element (CRE) is an important mechanism for a cAMP-mediated control of gene expression involved e.g. in spermiogenesis and memory/learning processes. This article discusses recent data leading to the hypothesis that this mechanism also contributes to altered gene regulation in heart failure.

引用

页码：11 / 17

页数：7

共 88 条

[1]

ARMSTRONG R, 1995, MOL CELL BIOL, V15, P1826

[2] CAMP CONCENTRATIONS, CAMP-DEPENDENT PROTEIN-KINASE ACTIVITY, AND PHOSPHOLAMBAN IN NONFAILING AND FAILING MYOCARDIUM [J].

BOHM, M ;

REIGER, B ;

SCHWINGER, RHG ;

ERDMANN, E .

CARDIOVASCULAR RESEARCH, 1994, 28 (11) :1713-1719

[3] INCREASE OF GI-ALPHA IN HUMAN HEARTS WITH DILATED BUT NOT ISCHEMIC CARDIOMYOPATHY [J].

BOHM, M ;

GIERSCHIK, P ;

JAKOBS, KH ;

PIESKE, B ;

SCHNABEL, P ;

UNGERER, M ;

ERDMANN, E .

CIRCULATION, 1990, 82 (04) :1249-1265

[4]

BRISTOW MR, 1989, MOL PHARMACOL, V35, P295

[5] DECREASED CATECHOLAMINE SENSITIVITY AND BETA-ADRENERGIC-RECEPTOR DENSITY IN FAILING HUMAN HEARTS [J].

BRISTOW, MR ;

GINSBURG, R ;

MINOBE, W ;

CUBICCIOTTI, RS ;

SAGEMAN, WS ;

LURIE, K ;

BILLINGHAM, ME ;

HARRISON, DC ;

STINSON, EB .

NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (04) :205-211

[6]

BRODDE OE, 1991, PHARMACOL REV, V43, P203

[7]

COLLINS S, 1990, J BIOL CHEM, V265, P19330

[8] CLONING AND SEQUENCE-ANALYSIS OF THE HUMAN BETA-1-ADRENERGIC RECEPTOR 5'-FLANKING PROMOTER REGION [J].

COLLINS, S ;

OSTROWSKI, J ;

LEFKOWITZ, RJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1172 (1-2) :171-174

[9]

Colucci WS, 1997, HEART DIS, P394

[10] Regulation of the rat atrial natriuretic peptide gene after acute imposition of left ventricular pressure overload [J].

Cornelius, T ;

Holmer, SR ;

Müller, FU ;

Riegger, GAJ ;

Schunkert, H .

HYPERTENSION, 1997, 30 (06) :1348-1355

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