Imidazo[1,2-a]pyridines with potent activity against herpesviruses

被引：113

作者：

Gudmundsson, Kristian S. ^{[1
]}

Johns, Brian A. ^{[1
]}

机构：

[1] GlaxoSmithKline Res & Dev Ltd, Dept Med Chem, Infect Dis Ctr Excellence Drug Discovery, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 10期

关键词：

imidazo[1,2-a]pyridine; antiherpetic; HSV;

D O I：

10.1016/j.bmcl.2007.02.079

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2-a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as other imidazopyridine substituents are outlined and resulting effects on antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2735 / 2739

页数：5

共 23 条

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