Flow instability and wall shear stress variation in intracranial aneurysms

被引:92
作者
Baek, H. [1 ]
Jayaraman, M. V. [2 ]
Richardson, P. D. [3 ,4 ]
Karniadakis, G. E. [1 ]
机构
[1] Brown Univ, Div Appl Math, Providence, RI 02912 USA
[2] Brown Univ, Dept Diagnost Imaging, Warren Alpert Sch Med, Providence, RI 02912 USA
[3] Brown Univ, Div Engn, Providence, RI 02912 USA
[4] Brown Univ, Dept Mol Pharmacol Physiol & Biotechnol, Providence, RI 02912 USA
关键词
flow instability; multiple aneurysms; spectral element method; CFD; NON-NEWTONIAN PROPERTIES; CEREBRAL ANEURYSM; BLOOD-FLOW; BOUNDARY-CONDITIONS; LARGE ARTERIES; HEMODYNAMICS; BIFURCATION; SIMULATION; TRANSITION; TURBULENCE;
D O I
10.1098/rsif.2009.0476
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
We investigate the flow dynamics and oscillatory behaviour of wall shear stress (WSS) vectors in intracranial aneurysms using high resolution numerical simulations. We analyse three representative patient-specific internal carotid arteries laden with aneurysms of different characteristics: (i) a wide-necked saccular aneurysm, (ii) a narrower-necked saccular aneurysm, and (iii) a case with two adjacent saccular aneurysms. Our simulations show that the pulsatile flow in aneurysms can be subject to a hydrodynamic instability during the decelerating systolic phase resulting in a high-frequency oscillation in the range of 20-50 Hz, even when the blood flow rate in the parent vessel is as low as 150 and 250 ml min(-1) for cases (iii) and (i), respectively. The flow returns to its original laminar pulsatile state near the end of diastole. When the aneurysmal flow becomes unstable, both the magnitude and the directions of WSS vectors fluctuate at the aforementioned high frequencies. In particular, the WSS vectors around the flow impingement region exhibit significant spatio-temporal changes in direction as well as in magnitude.
引用
收藏
页码:967 / 988
页数:22
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