Epigenetic regulation of neural gene expression and neuronal function

被引：195

作者：

Feng, Jian ^{[1
]}

Fouse, Shaun ^{[1
]}

Fan, Guoping ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

来源：

PEDIATRIC RESEARCH | 2007年 / 61卷 / 05期

关键词：

D O I：

10.1203/pdr.0b013e3180457635

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

The development and function of the CNS requires accurate gene transcription control in response to proper environmental signals. Epigenetic mechanisms, including DNA methylation, histone modifications, and other chromatin-remodeling events, are critically important in mediating precise neural gene regulation. This review focuses on discussing the role of DNA methylation and histone modifications in neural lineage differentiation, synaptic plasticity and neural behavior. We postulate that DNA methylation-and histone modification-mediated gene regulation is not only important for neural cell differentiation but also crucial for high-order cognitive functions such as learning and memory.

引用

页码：58R / 63R

页数：6

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