Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro

被引：51

作者：

Chang, JS

Chiang, LC

Hsu, FF

Lin, CC

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung 807, Taiwan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2004年 / 32卷 / 05期

关键词：

Cornus officinalis; free radical; hepatocellular carcinoma; p53; Ras;

D O I：

10.1142/S0192415X04002296

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The water extracts of Cornus officinalis Sieb. et Zuce against hepatocellular carcinoma (HCC) was studied for its chemopreventive potential. Three HCC cell lines (HepG2, SK-Hep1 and PLC/PRF/5) and three leukemic cell lines (U937, K562 and Raji) were tested with XTT assay. Extracts of C. officinalis inhibited all these HCC cells and leukemic cells at a concentration of 100 mug/ml (P < 0.05) and was dose-dependent (P < 0.0001). P53 (P < 0.0001) and Ras (P = 0.001) significantly affected its activity against HCC. Extracts of C. officinalis also possessed the anti-oxidant activity through free radicals scavenging activity at a concentration of 50 mug/ml (P < 0.05). In summary, our experiment implied that C. officinalis might be a candidate for chemopreventive agent against HCC through the antioxidant and anti-neoplastic effects.

引用

页码：717 / 725

页数：9

共 27 条

[1] Green tea catechins partially protect DNA from (.)OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals [J].