Synthesis, resolution, and applications of 2,2′-bis(diphenylphosphino)-3,3′-binaphtho[2,1-b]furan

被引：68

作者：

Andersen, NG ^{[1
]}

Parvez, M ^{[1
]}

Keay, BA ^{[1
]}

机构：

[1] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 18期

关键词：

D O I：

10.1021/ol006238+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short five-step synthesis of (+/-)-2,2'-bis(diphenylphosphino)-3,3'-binaphtho[2,1-b](BINAPFu, 1) starting from 2-naphthoxyacetic acid is reported. The resolution of BINAPFu 1 was possible using our newly developed resolution procedure for phosphines wherein (1 S)-camphorsulfonyl azide was used to prepare the bisphosphinimine of BINAPFu via the Staundinger reaction. BINAPFu consistently outperformed BINAP in an asymmetric Heck reaction between 2,3 dihydrofuran and phenyl triflate.

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页码：2817 / 2820

页数：4

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