Sending proteins to dense core secretory granules: still a lot to sort out

被引:98
作者
Dikeakos, Jimmy D. [1 ]
Reudelhuber, Timothy L. [1 ]
机构
[1] Clin Res Inst Montreal, Lab Mol Biochem Hypertens, Montreal, PQ H2W 1R7, Canada
关键词
D O I
10.1083/jcb.200701024
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The intracellular sorting of peptide hormone precursors to the dense core secretory granules (DCSGs) is essential for their bioactivation. Despite the fundamental importance of this cellular process, the nature of the sorting signals for entry of proteins into DCSGs remains a source of vigorous debate. This review highlights recent discoveries that are consistent with a model in which several protein domains, acting in a cell-specific fashion and at different steps in the sorting process, act in concert to regulate the entry of proteins into DCSGs.
引用
收藏
页码:191 / 196
页数:6
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