Age-related decline in the functional response of striatal group I mGlu receptors

被引：13

作者：

Pintor, A ^{[1
]}

Potenza, RL ^{[1
]}

Domenici, MR ^{[1
]}

Tiburzi, F ^{[1
]}

Reggio, R ^{[1
]}

Pèzzola, A ^{[1
]}

Popoli, P ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Pharmacol, I-00161 Rome, Italy

来源：

NEUROREPORT | 2000年 / 11卷 / 13期

关键词：

ageing; DHPG; dopamine release; extracellular FP; mGlu receptors; PI hydrolysis;

D O I：

10.1097/00001756-200009110-00041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to verify whether striatal group I metabotropic glutamate (mGlu) receptors undergo functional alteration in ageing, the effects induced by the selective agonist 3,5-dihydroxyphenylglycine (DHPG) in the striatum of young (3 months) and aged (24-25 months old) rats were compared. The ability of DHPG to stimulate phosphoinositide (PI) hydrolysis (striatal slices), to influence striatal dopamine release (in vivo microdialysis) and to potentiate the effects of NMDA on extracellular field potential amplitude (extracellular recordings on striatal slices) was reduced in the striatum of old vs young rats. These results show an age-dependent reduction in the functional response of striatal group 1 mGlu receptors. which may be one of the factors underlying the reduced ability of aged striatum to integrate information. NeuroReport 11:3033-3038 (C) 2000 Lippincott Williams & Wilkins.

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收藏

页码：3033 / 3038

页数：6

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