Syntheses of D- and L-myo-inositol 1,2,4,5-tetrakisphosphate and stereoselectivity of the I(1,4,5)P3 receptor binding

被引：18

作者：

Chung, SK ^{[1
]}

Shin, BG

Chang, YT

Suh, BC

Kim, KT

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, South Korea

[2] Pohang Univ Sci & Technol, Dept Life Sci, Pohang 790784, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(98)00081-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

D- and L-myo-Inositol 1,2,4,5-tetrakisphosphate [D- & L-I(1,2,4,5)P-4], which are analogues of D-myo-Inositol 1,4,5-trisphosphate [D-I(1,4,5)P-3], a calcium mobilizing second messenger, were synthesized via resolution of the camphanate ester of a myo-inositol derivative, and the binding affinities to I(1,4,5)P-3 receptor were measured. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：659 / 662

页数：4

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