Moving away from the midline: new developments for Slit and Robo

被引：180

作者：

Ypsilanti, Athena R. ^{[1
,2
,3
]}

Zagar, Yvrick ^{[1
,2
,3
]}

Chedotal, Alain ^{[1
,2
,3
]}

机构：

[1] INSERM, U968, F-75012 Paris, France

[2] UPMC Univ Paris 06, UMR S 968, Inst Vis, F-75012 Paris, France

[3] CNRS, UMR 7210, F-75012 Paris, France

来源：

DEVELOPMENT | 2010年 / 137卷 / 12期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Axon guidance; Cell migration; Cell-cell interaction; HEPARAN-SULFATE PROTEOGLYCANS; GTPASE-ACTIVATING PROTEINS; HORIZONTAL GAZE PALSY; SENSORY NEURON AXONS; CELL-MIGRATION; GROWTH CONE; DISTINCT ROLES; MESSENGER-RNA; DIFFERENTIAL EXPRESSION; PRECEREBELLAR NEURONS;

D O I：

10.1242/dev.044511

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In most tissues, the precise control of cell migration and cell-cell interaction is of paramount importance to the development of a functional structure. Several families of secreted molecules have been implicated in regulating these aspects of development, including the Slits and their Robo receptors. These proteins have well described roles in axon guidance but by influencing cell polarity and adhesion, they participate in many developmental processes in diverse cell types. We review recent progress in understanding both the molecular mechanisms that modulate Slit/Robo expression and their functions in neural and non-neural tissue.

引用

页码：1939 / 1952

页数：14

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