Risk Factors for Severe Rift Valley Fever Infection in Kenya, 2007

被引：129

作者：

Anyangu, Amwayi S. ^{[4
]}

Gould, L. Hannah ^{[1
]}

Sharif, Shahnaaz K.

Nguku, Patrick M. ^{[5
]}

Omolo, Jared O. ^{[6
]}

Mutonga, David ^{[6
]}

Rao, Carol Y. ^{[7
]}

Lederman, Edith R. ^{[8
]}

Schnabel, David

Paweska, Janusz T. ^{[3
]}

Katz, Mark

Hightower, Allen

Njenga, M. Kariuki

Feikin, Daniel R.

Breiman, Robert F. ^{[2
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA USA

[2] CDC Kenya, Global Dis Detect Div, Int Emerging Infect Program, Nairobi, Kenya

[3] Natl Inst Communicable Dis, Special Pathogens Unit, Johannesburg, South Africa

[4] Prov Headquarters N Eastern Prov, Garissa, Kenya

[5] Minist Hlth, Div Communicable Dis Control, Nairobi, Kenya

[6] Minist Hlth, Div Dis Surveillance & Response, Nairobi, Kenya

[7] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA

[8] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div Viral & Rickettisial Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2010年 / 83卷 / 02期

关键词：

SAUDI-ARABIA; OUTBREAK; VIRUS; EPIDEMIC; DISEASE; HUMANS; EGYPT; QUANTIFICATION; HEPATITIS; ANTIBODY;

D O I：

10.4269/ajtmh.2010.09-0293

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A large Rift Valley fever (RVF) outbreak occurred in Kenya from December 2006 to March 2007. We conducted a study to define risk factors associated with infection and severe disease. A total of 861 individuals from 424 households were enrolled. Two hundred and two participants (23%) had serologic evidence of acute RVF infection. Of these, 52 (26%) had severe RVF disease characterized by hemorrhagic manifestations or death. Independent risk factors for acute RVF infection were consuming or handling products from sick animals (odds ratio [OR] = 2.53, 95% confidence interval [CI] = 1.78-3.61, population attributable risk percentage [PAR%] = 19%) and being a herdsperson (OR 1.77,95% CI = 1.20-2.63, PAR% = 11%). Touching an aborted animal fetus was associated with severe RVF disease (OR = 3.83,95% CI = 1.68-9.07, PAR% = 14%). Consuming or handling products from sick animals was associated with death (OR = 3.67,95% CI = 1.07-12.64, PAR% = 47%). Exposures related to animal contact were associated with acute RVF infection, whereas exposures to mosquitoes were not independent risk factors.

引用

页码：14 / 21

页数：8

共 46 条

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