The (r)evolution of cancer genetics

被引：10

作者：

Ciccarelli, Francesca D. ^{[1
]}

机构：

[1] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

来源：

BMC BIOLOGY | 2010年 / 8卷

关键词：

MYELOID-LEUKEMIA GENOME; COLORECTAL CANCERS; SOMATIC MUTATIONS; GENES; BREAST; PATHWAYS; DUPLICABILITY; NETWORK;

D O I：

10.1186/1741-7007-8-74

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The identification of an increasing number of cancer genes is opening up unexpected scenarios in cancer genetics. When analyzed for their systemic properties, these genes show a general fragility towards perturbation. A recent paper published in BMC Biology shows how the founder domains of known cancer genes emerged at two macroevolutionary transitions the advent of the first cell and the transition to metazoan multicellularity.

引用

页数：4

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