Antiandrogenic phenolic constituents from Dalbergia cochinchinensis

被引：53

作者：

Pathak, V

Shirota, O

Sekita, S

Hirayama, Y

Hakamata, Y

Hayashi, T

Yanagawa, T

Satake, M

机构：

[1] Natl Inst Hlth Sci, Div Pharmacognosy & Phytochem, Setagaya Ku, Tokyo 158, Japan

[2] Lion Corp, Biol Sci Res Ctr, Res & Dev Headquarters, Odawara, Kanagawa 256, Japan

来源：

PHYTOCHEMISTRY | 1997年 / 46卷 / 07期

关键词：

Dalbergia cochinchinensis; Leguminosae; flavone; neoflavene; benzophenone; spectroscopic analysis; antiandrogenic activity;

D O I：

10.1016/S0031-9422(97)80015-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new compounds, 9-hydroxy-6,7-dimethoxydalbergiquinol, 6-hydroxy-2,7-dimethoxy-neoflavene, 6,4'-dihydroxy-7-methoxyflavan and 2,2',5-trihydroxy-4-methoxybenzophenone, in addition to eight known phenolic compounds including 7-hydroxy-6-methoxyflavone, have been isolated from the stems of Dalbergia cochinchinensis. Their structures were established by spectroscopic techniques including one-and two-dimensional NMR methods. The first two compounds showed potent inhibitory activity towards 5 alpha-dihydrotestosterone (DHT) which binds with an androgen receptor to form a DHT-receptor complex that causes androgen-dependent diseases. (C) 1997 Elsevier Science Ltd.

引用

页码：1219 / 1223

页数：5

共 13 条

[1]

AGRAWAL PK, 1988, NMR NATURAL PRODUCTS, V1

[2]

BHARDWAJ DK, 1988, P INDIAN NATL ACAD A, V54, P638

[3] METABOLISM OF TESTOSTERONE BY HUMAN MALE SCALP SKIN [J].