Tissue Doppler imaging detects early asymptomatic myocardial abnormalities in a dog model of Duchenne's cardiomyopathy

Aims Early diagnosis of Duchenne's dilated cardiomyopathy remains a challenge for conventional echocardiography. We sought to determine whether tissue Doppler imaging (TDI) could detect early alteration in myocardial function in a dog model of Duchenne muscular dystrophy, i.e. the Golden Retriever Muscular Dystrophy (GRMD). Methods and results Myocardial function was assessed by TDI in 20 dogs with normal conventional parameters of systolic function (eight controls and 12 GRMD, 25 +/- 11 weeks) without knowledge of the genotype. M-mode TDI was recorded from a short-axis view for measurement of endocardial. and epicardial velocities and myocardial velocity gradient (MVG) within the posterior wall. Controls and GRMD dogs were comparable regarding Left ventricular fractional shortening (37 +/- 2 vs 42 +/- 3%, p = ns). Conversely, TDI showed, in all GRMD dogs, a dramatic decrease in systolic MVG (0.8 +/- 0.1 vs 2.9 +/- 0.3 s(-1), p < 0.0001) and early diastolic MVG (2.3 +/- 2.2 vs 10.8 +/- 1.1 s(-1), p < 0.0001). This MVG alteration was related to a significant decrease in endocardial velocities in GRMD whereas epicardial. velocities were comparable in the two groups. Conclusion These results show that TDI is more sensitive than conventional echocardiography in detecting pre-clinical myocardial abnormalities before occurrence of left ventricular dilation and dysfunction. TDI should be part of the screening techniques for the early diagnosis of cardiomyopathy. (C) 2004 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.