A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculations

被引：51

作者：

Ma, ZM

Abel, K

Rourke, T

Wang, YC

Miller, CJ

机构：

[1] Univ Calif Davis, CNPRC, CCM, Davis, CA 95616 USA

[2] Univ Calif Davis, Sch Vet Med, Dept Plant Microbiol & Immunol, Davis, CA 95616 USA

[3] Univ Calif Davis, Sch Med, Div Infect Dis, Davis, CA 95616 USA

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 24期

关键词：

D O I：

10.1128/JVI.78.24.14048-14052.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In rhesus macaques, classic systemic infection, characterized by persistent viremia and seroconversion, occurred after multiple low-dose (10(3) 50% tissue culture infective doses) intravaginal (IVAG) inoculations with simian immunodeficiency virus (SIV) strain SIVmac251. Monkeys developed classic SIV infections after a variable number of low-dose IVAG exposures to SIVmac251. Once established, the systemic infection was identical to SIV infection following high-dose IVAG SIV inoculation. However, occult systemic infection characterized by transient cell-associated or cell-free viremia consistently occurred early in the series of multiple vaginal SIV exposures. Further, antiviral cellular immune responses were present prior to the establishment of a classic systemic infection in the low-dose vaginal SIV transmission model.

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收藏

页码：14048 / 14052

页数：5

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