Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae

被引：74

作者：

García-Rodriguez, LJ

Trilla, JA

Castro, C

Valdivieso, MH

Durán, A

Roncero, C

机构：

[1] Univ Salamanca, Consejo Super Invest Cient, Inst Microbiol Bioquim, Salamanca 37007, Spain

[2] Univ Salamanca, Dept Genet & Microbiol, Salamanca 37007, Spain

来源：

FEBS LETTERS | 2000年 / 478卷 / 1-2期

关键词：

chitin; compensatory mechanism; chitin synthase III activity;

D O I：

10.1016/S0014-5793(00)01835-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deletion of the 1,3-beta-D-glucan synthase gene FKS1 in Saccharomyces cerevisiae induces a compensatory mechanism that is reflected in a significant increase in chitin synthase III (CSIII) activity, leading to high rates of chitin synthesis. Deregulation of CSIII activity is mainly due to the intracellular delocalization of Chs3p and Chs4p, the two main components of the CSIII active complex. (C) 2000 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.

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页码：84 / 88

页数：5

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