Impairment of sensorimotor gating in mice deficient in the cell adhesion molecule L1 or its close homologue, CHL1

被引：38

作者：

Irintchev, A

Koch, M

Needham, LK

Maness, P

Schachner, M

机构：

[1] Univ Hamburg, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany

[2] Univ Bremen, Brain Res Inst, D-28334 Bremen, Germany

[3] Univ N Carolina, Sch Med, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

来源：

BRAIN RESEARCH | 2004年 / 1029卷 / 01期

关键词：

startle response; prepulse inhibition; L1CAM; CHL1; mouse; mutation;

D O I：

10.1016/j.brainres.2004.09.042

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mutations in the gene encoding the cell adhesion molecule L1 or its close homologue, CHL1 (close homologue of L1), cause brain dysfunction in both humans and mice. Here we report that prepulse inhibition (PPI) of the acoustic startle response is impaired in mice deficient in either L1 or CHL1. This newly identified feature may provide a basis for using these mice as models for sensorimotor gating impairment found in some neuropsychiatric disorders such as schizophrenia. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：131 / 134

页数：4

共 18 条

[1] Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies [J].

Braff, DL ;

Geyer, MA ;

Swerdlow, NR .

PSYCHOPHARMACOLOGY, 2001, 156 (2-3) :234-258

[2] Disruption of the mouse L1 gene leads to malformations of the nervous system [J].

Dahme, M ;

Bartsch, U ;

Martini, R ;

Anliker, B ;

Schachner, M ;

Mantei, N .

NATURE GENETICS, 1997, 17 (03) :346-349

[3] Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex [J].

Demyanenko, GP ;

Schachner, M ;

Anton, E ;

Schmid, R ;

Feng, GP ;

Sanes, J ;

Maness, PF .

NEURON, 2004, 44 (03) :423-437

[4]

Demyanenko GP, 1999, J NEUROSCI, V19, P4907

[5]

Dihné M, 2003, J NEUROSCI, V23, P6638

[6] CALL interrupted in a patient with non-specific mental retardation:: gene dosage-dependent alteration of murine brain development and behavior [J].

Frints, SGM ;

Marynen, P ;

Hartmann, D ;

Fryns, JP ;

Steyaert, J ;

Schachner, M ;

Rolf, B ;

Craessaerts, K ;

Snellinx, A ;

Hollanders, K ;

D'Hooge, R ;

De Deyn, PP ;

Froyen, G .

HUMAN MOLECULAR GENETICS, 2003, 12 (13) :1463-1474

[7] Role of L1 in neural development: What the knockouts tell us [J].

Kamiguchi, H ;

Hlavin, ML ;

Lemmon, V .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1998, 12 (1-2) :48-55

[8]

Kurumaji A, 2001, AM J MED GENET, V105, P99

[9]

Law JWS, 2003, J NEUROSCI, V23, P10419

[10] Genome scan meta-analysis of schizophrenia and bipolar disorder, part II:: Schizophrenia [J].

Lewis, CM ;

Levinson, DF ;

Wise, LH ;

DeLisi, LE ;

Straub, RE ;

Hovatta, I ;

Williams, NM ;

Schwab, SG ;

Pulver, AE ;

Faraone, SV ;

Brzustowicz, LM ;

Kaufmann, CA ;

Garver, DL ;

Gurling, HMD ;

Lindholm, E ;

Coon, H ;

Moises, HW ;

Byerley, W ;

Shaw, SH ;

Mesen, A ;

Sherrington, R ;

O'Neill, FA ;

Walsh, D ;

Kendler, KS ;

Ekelund, J ;

Paunio, T ;

Lönnqvist, J ;

Peltonen, L ;

O'Donovan, MC ;

Owen, MJ ;

Wildenauer, DB ;

Maier, W ;

Nestadt, G ;

Blouin, JL ;

Antonarakis, SE ;

Mowry, BJ ;

Silverman, JM ;

Crowe, RR ;

Cloninger, CR ;

Tsuang, MT ;

Malaspina, D ;

Harkavy-Friedman, JM ;

Svrakic, DM ;

Bassett, AS ;

Holcomb, J ;

Kalsi, G ;

McQuillin, A ;

Brynjolfson, J ;

Sigmundsson, T ;

Petursson, H .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (01) :34-48

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