Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia

被引：185

作者：

Williams, NM ^{[1
]}

Preece, A ^{[1
]}

Spurlock, G ^{[1
]}

Norton, N ^{[1
]}

Williams, HJ ^{[1
]}

Zammit, S ^{[1
]}

O'Donovan, MC ^{[1
]}

Owen, MJ ^{[1
]}

机构：

[1] Cardiff Univ, Dept Psychol Med, Cardiff CF14 4XN, S Glam, Wales

来源：

MOLECULAR PSYCHIATRY | 2003年 / 8卷 / 05期

关键词：

schizophrenia; neuregulin; 1; genetics;

D O I：

10.1038/sj.mp.4001348

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, it has been reported that genetic variants around the gene neuregulin 1 are associated with schizophrenia in an Icelandic sample. Of particular interest was the presence of a single-risk haplotype that was significantly over-represented in schizophrenic individuals compared to controls (15.4 : 7.5%, P = 6.7 x 10(-6)). We have attempted to replicate this result in our large collection of 573 schizophrenia cases and 618 controls. We found that the risk haplotype was more common in cases than controls (9.5 : 7.5%; P = 0.04), and especially in our subset of 141 cases with a family history of schizophrenia (11.6%; P = 0.019). Our results therefore replicate the Icelandic findings in an out-bred Northern European population, although they suggest that the risk conferred by the haplotype is small.

引用

页码：485 / 487

页数：3

共 13 条

[1] Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21 [J].

Blouin, JL ;

Dombroski, BA ;

Nath, SK ;

Lasseter, VK ;

Wolyniec, PS ;

Nestadt, G ;

Thornquist, M ;

Ullrich, G ;

McGrath, J ;

Kasch, L ;

Lamacz, M ;

Thomas, MG ;

Gehrig, C ;

Radhakrishna, U ;

Snyder, SE ;

Balk, KG ;

Neufeld, K ;

Swartz, KL ;

DeMarchi, N ;

Papadimitriou, GN ;

Dikeos, DG ;

Stefanis, CN ;

Chakravarti, A ;

Childs, B ;

Housman, DE ;

Kazazian, HH ;

Antonarakis, SE ;

Pulver, AE .

NATURE GENETICS, 1998, 20 (01) :70-73

[2]

Chen XN, 1999, GENOME RES, V9, P492

[3]

Kaufmann CA, 1998, AM J MED GENET, V81, P282, DOI 10.1002/(SICI)1096-8628(19980710)81:4<282::AID-AJMG2>3.3.CO

[4]

2-R

[5]

Kendler KS, 1996, AM J PSYCHIAT, V153, P1534

[6] Diagnostic and Statistical Manual of Mental Disorders [J].

Mittal, Vijay A. ;

Walker, Elaine F. .

PSYCHIATRY RESEARCH, 2011, 189 (01) :158-159

[7] Association of neuregulin 1 with schizophrenia confirmed in a Scottish population [J].

Stefansson, H ;

Sarginson, J ;

Kong, A ;

Yates, P ;

Steinthorsdottir, V ;

Gudfinnsson, E ;

Gunnarsdottir, S ;

Walker, N ;

Petursson, H ;

Crombie, C ;

Ingason, A ;

Gulcher, JR ;

Stefansson, K ;

St Clair, D .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (01) :83-87

[8] Neuregulin 1 and susceptibility to schizophrenia [J].

Stefansson, H ;

Sigurdsson, E ;

Steinthorsdottir, V ;

Bjornsdottir, S ;

Sigmundsson, T ;

Ghosh, S ;

Brynjolfsson, J ;

Gunnarsdottir, S ;

Ivarsson, O ;

Chou, TT ;

Hjaltason, O ;

Birgisdottir, B ;

Jonsson, H ;

Gudnadottir, VG ;

Gudmundsdottir, E ;

Bjornsson, A ;

Ingvarsson, B ;

Ingason, A ;

Sigfusson, S ;

Hardardottir, H ;

Harvey, RP ;

Lai, D ;

Zhou, MD ;

Brunner, D ;

Mutel, V ;

Gonzalo, A ;

Lemke, G ;

Sainz, J ;

Johannesson, G ;

Andresson, T ;

Gudbjartsson, D ;

Manolescu, A ;

Frigge, ML ;

Gurney, ME ;

Kong, A ;

Gulcher, JR ;

Petursson, H ;

Stefansson, K .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (04) :877-892

[9] A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs [J].

Williams, NM ;

Rees, MI ;

Holmans, P ;

Norton, N ;

Cardno, AG ;

Jones, LA ;

Murphy, KC ;

Sanders, RD ;

McCarthy, G ;

Gray, MY ;

Fenton, I ;

McGuffin, P ;

Owen, MJ .

HUMAN MOLECULAR GENETICS, 1999, 8 (09) :1729-1739

[10]

Wing J.K., 1974, The measurement and classification of psychiatric symptoms

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