Disposition characteristics of emulsions and incorporated drugs after systemic or local injection

被引：58

作者：

Kawakami, S

Yamashita, F

Hashida, M ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Drug Delivery REs, Sakyo Ku, Kyoto 6068501, Japan

[2] Nagasaki Univ, Sch Pharmaceut Sci, Nagasaki 8258521, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2000年 / 45卷 / 01期

关键词：

lipid emulsion; drug delivery system; targeting; controlled release; gene delivery; prodrug;

D O I：

10.1016/S0169-409X(00)00102-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lipid emulsions an useful tools for controlling the in vivo disposition of drugs and plasmid DNA. The dispositions of lipid emulsions are determined by their tissue interaction depending on the anatomical and physiological characteristics of each tissue and the physicochemical and biological properties of lipid emulsions, in addition, the retention of drugs is another issue, as too rapid a release of the drug would lead to failure of exerting its therapeutic potency. This review presents an overview about the disposition profiles and various physicochemical properties of lipid emulsions and incorporated drugs after systemic or local injection. Controlled biodistribution of lipid emulsions and incorporated drugs are also discussed. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：77 / 88

页数：12

共 82 条

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