An agenda for personalized medicine

被引：228

作者：

Ng, Pauline C. ^{[1
]}

Venter, J. Craig ^{[1
]}

Murray, Sarah S. ^{[2
]}

Levy, Samuel ^{[3
]}

机构：

[1] J Craig Venter Inst, San Diego, CA 92121 USA

[2] Scripps Translat Sci Inst, La Jolla, CA 92037 USA

[3] J Craig Venter Inst, Rockville, MD 20850 USA

来源：

NATURE | 2009年 / 461卷 / 7265期

关键词：

ADVERSE DRUG-REACTIONS; CELIAC-DISEASE; RISK-FACTORS; VARIANTS; DATABASE;

D O I：

10.1038/461724a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pauline C. Ng, Sarah S. Murray, Samuel Levy and J. Craig Venter find differences in results from two direct-toconsumer genetics-testing companies. They therefore give nine recommendations to improve predictions.

引用

页码：724 / 726

页数：3

共 23 条

[1] Genetic Variants Associated with Complex Human Diseases Show Wide Variation across Multiple Populations [J].

Adeyemo, A. ;

Rotimi, C. .

PUBLIC HEALTH GENOMICS, 2010, 13 (02) :72-79

[2]

[Anonymous], PERS GEN IND STAND S

[3] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts [J].

Aulchenko, Yurii S. ;

Ripatti, Samuli ;

Lindqvist, Ida ;

Boomsma, Dorret ;

Heid, Iris M. ;

Pramstaller, Peter P. ;

Penninx, Brenda W. J. H. ;

Janssens, A. Cecile J. W. ;

Wilson, James F. ;

Spector, Tim ;

Martin, Nicholas G. ;

Pedersen, Nancy L. ;

Kyvik, Kirsten Ohm ;

Kaprio, Jaakko ;

Hofman, Albert ;

Freimer, Nelson B. ;

Jarvelin, Marjo-Riitta ;

Gyllensten, Ulf ;

Campbell, Harry ;

Rudan, Igor ;

Johansson, Asa ;

Marroni, Fabio ;

Hayward, Caroline ;

Vitart, Veronique ;

Jonasson, Inger ;

Pattaro, Cristian ;

Wright, Alan ;

Hastie, Nick ;

Pichler, Irene ;

Hicks, Andrew A. ;

Falchi, Mario ;

Willemsen, Gonneke ;

Hottenga, Jouke-Jan ;

de Geus, Eco J. C. ;

Montgomery, Grant W. ;

Whitfield, John ;

Magnusson, Patrik ;

Saharinen, Juha ;

Perola, Markus ;

Silander, Kaisa ;

Isaacs, Aaron ;

Sijbrands, Eric J. G. ;

Uitterlinden, Andre G. ;

Witteman, Jacqueline C. M. ;

Oostra, Ben A. ;

Elliott, Paul ;

Ruokonen, Aimo ;

Sabatti, Chiara ;

Gieger, Christian ;

Meitinger, Thomas .

NATURE GENETICS, 2009, 41 (01) :47-55

[4] Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database [J].

Bertram, Lars ;

McQueen, Matthew B. ;

Mullin, Kristina ;

Blacker, Deborah ;

Tanzi, Rudolph E. .

NATURE GENETICS, 2007, 39 (01) :17-23

[5]

Duncan David Ewing, 2009, EXPT MAN WHAT ONE MA

[6] A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes [J].

Easton, Douglas F. ;

Deffenbaugh, Amie M. ;

Pruss, Dmitry ;

Frye, Cynthia ;

Wenstrup, Richard J. ;

Allen-Brady, Kristina ;

Tavtigian, Sean V. ;

Monteiro, Alvaro N. A. ;

Iversen, Edwin S. ;

Couch, Fergus J. ;

Goldgar, David E. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (05) :873-883

[7] Human genetic variation and its contribution to complex traits [J].

Frazer, Kelly A. ;

Murray, Sarah S. ;

Schork, Nicholas J. ;

Topol, Eric J. .

NATURE REVIEWS GENETICS, 2009, 10 (04) :241-251

[8] Coeliac disease [J].

Green, PHR ;

Jabri, B .

LANCET, 2003, 362 (9381) :383-391

[9] A systematic review of perceived risks, psychological and behavioral impacts of genetic testing [J].

Heshka, Jodi T. ;

Palleschi, Crystal ;

Howley, Heather ;

Wilson, Brenda ;

Wells, Philip S. .

GENETICS IN MEDICINE, 2008, 10 (01) :19-32

[10] The current landscape for direct-to-consumer genetic testing: Legal, ethical, and policy issues [J].

Hogarth, Stuart ;

Javitt, Gail ;

Melzer, David .

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2008, 9 :161-182

← 1 2 3 →