Inhaled nitric oxide in acute respiratory distress syndrome

被引：19

作者：

Johannigman, JA ^{[1
]}

Davis, K ^{[1
]}

Campbell, RS ^{[1
]}

Luchette, F ^{[1
]}

Hurst, JM ^{[1
]}

Branson, RD ^{[1
]}

机构：

[1] Univ Cincinnati, Med Ctr, Dept Surg, Cincinnati, OH 45267 USA

来源：

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE | 1997年 / 43卷 / 06期

关键词：

D O I：

10.1097/00005373-199712000-00006

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: Inhaled nitric oxide has been shown to improve oxygenation in select patients with acute respiratory distress syndrome (ARDS), Objective: The purpose of this study nas to evaluate the clinical response to four concentrations of inhaled nitric oxide (NO) in 20 patients with ARDS. Methods: All patients with ARDS were eligible for the study. ARDS was defined as (1) the presence of a predisposing factor; (2) a Pao(2)/Fio(2) ratio < 200; (3) bilateral infiltrates on chest radiograph: and (4) absence of evidence of congestive heart failure and pulmonary artery a edge pressure < 18 mm Hg. Patients received each of four doses (1, 15, 30, and 60 ppm) in random order, each for a 3-hour period, Cardiovascular variables were continuously monitored, and arterial and mixed venous blood gas measurements were obtained at 30 minutes and 3 hours.

引用

页码：904 / 909

页数：6

共 20 条

[1]

BERNARD GR, 1993, J CRIT CARE, V6, P1

[2] PROLONGED INHALATION OF LOW CONCENTRATIONS OF NITRIC-OXIDE IN PATIENTS WITH SEVERE ADULT-RESPIRATORY-DISTRESS-SYNDROME - EFFECTS ON PULMONARY HEMODYNAMICS AND OXYGENATION [J].