Biologically active phenols from Saussurea medusa

被引：73

作者：

Fan, CQ ^{[1
]}

Yue, JM ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Drug Res, Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0968-0896(02)00470-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sixteen phenolic compounds were isolated from the polar fraction of Saussurea medusa and were structurally elucidated by chemical evidences and spectral methods. These compounds include two new lignan glucosides, namely medusasides A (1) and B (2), and fourteen known phenolic compounds (3-16). One major compound, apigenin 7-O-[alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside] (6) showed remarkable activity to attenuate the scopolamine induced memory deficit of mice. Compound 6 and another major one, querectin (8) also exhibited moderate cell protecting activities against hydrogen peroxide (H2O2) induced PC12 cell damage. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：703 / 708

页数：6

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