Differential effects of selective vagotomy and tropisetron in aminoprivic feeding

被引:14
作者
Dixon, KD
Williams, FE
Wiggins, RL
Pavelka, J
Lucente, J
Bellinger, LL
Gietzen, DW
机构
[1] Univ Calif Davis, Sch Vet Med, Dept Anat Physiol & Cell Biol, Davis, CA 95616 USA
[2] Univ Calif Davis, Food Intake Lab, Davis, CA 95616 USA
[3] Texas A&M Univ, Hlth Sci Ctr, Baylor Coll Dent, Dept Biol Sci, Dallas, TX 75246 USA
关键词
amino acid; diet; amino acid-imbalanced diet; amino acid deficiency; rat; food intake; body weight; vagus; serotonin;
D O I
10.1152/ajpregu.2000.279.3.R997
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Both total subdiaphragmatic vagotomy (TVAGX) and serotonin(3) receptor blockade with tropisetron or ondansetron attenuate amino acid-imbalanced diet (Imb) anorexia. Total vagotomy is less effective than tropisetron in reducing Imb-induced anorexia and also blunts the tropisetron effect. With the use of electrocautery at the subdiaphragmatic level of the vagus, we severed the ventral and dorsal trunks as well as the hepatic, ventral gastric, dorsal gastric, celiac, and accessory celiac branches separately or in combination to determine which vagal branches or associated structures may be involved in these responses. Rats were prefed a low-protein diet. On the first experimental day, tropisetron or saline was given intraperitoneally 1 h before presentation of Imb. Cuts including the ventral branch, i.e., TVAGX, ventral vagotomy (above the hepatic branch), and hepatic 1 gastric vagotomies (but not hepatic branch cuts alone) caused the highest (P< 0.05) Imb intake on day 1 with or without tropisetron. The responses to tropisetron were not affected significantly. On days 2-8, groups having vagotomies that included the hepatic branch recovered faster than sham-treated animals. Because the hepatic and gastric branches together account for most of the vagal innervation to the proximal duodenum, this area may be important in the initial responses, whereas structures served by the hepatic branch alone apparently act in the later adaptation to Imb.
引用
收藏
页码:R997 / R1009
页数:13
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