Alcohol consumption and other risk factors for self-reported diabetes among middle-aged Japanese: a population-based prospective study in the JPHC study cohort I

被引:136
作者
Waki, K
Noda, M
Sasaki, S
Matsumura, Y
Takahashi, Y
Isogawa, A
Ohashi, Y
Kadowaki, T
Tsugane, S
机构
[1] Natl Canc Ctr, Epidemiol & Prevent Div, Res Ctr Canc Prevent & Screening, Chuo Ku, Tokyo 1040045, Japan
[2] Univ Tokyo, Dept Biostat, Grad Sch Med, Tokyo, Japan
[3] Natl Inst Hlth & Nutr, Tokyo 162, Japan
[4] Toranomon Gen Hosp, Dept Endocrinol & Metab, Tokyo, Japan
[5] Univ Tokyo, Dept Metab Dis, Grad Sch Med, Tokyo, Japan
关键词
diabetes mellitus; prospective study; risk factor;
D O I
10.1111/j.1464-5491.2004.01403.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims Few prospective studies have examined the relationship between lifestyle characteristics and the incidence of diabetes mellitus in an Asian general population. This study was undertaken to evaluate the risk factors for Type 2 diabetes in a population-based prospective study of middle-aged Japanese. Methods We investigated 12 913 men and 15 980 women, aged 40-59 years at baseline (year 0), who participated in the Japan Public Health Center-based prospective study on cancer and cardiovascular diseases (JPHC Study) Cohort I. The participants were followed for up to 10 years. Incident cases of diabetes were identified by self-reporting of a physician's diagnosis on two questionnaires sent to each participant, one at year 5 and the second at year 10. Results During the 10-year follow-up, 703 men and 482 women reported newly diagnosed diabetes. Age, body mass index (BMI), family history of diabetes and cigarette smoking were independent risk factors in both genders by multivariate analysis. Among men with a BMI less than or equal to 22 kg/m(2), a significant positive association was observed between the diabetes incidence and moderate (23.0 < 46.0 g/day) to high (> 46.0 g/day) alcohol consumption, odds ratio 1.91 (95% CI, 1.05-3.46) and 2.89 (1.63-5.11), respectively. Among men with a BMI > 22 kg/m(2), a small non-significant increase in odds ratio was observed with alcohol consumption. Conclusions Established risk factors for diabetes in western populations were also identified as predictors of the disease among Japanese. Moderate to high alcohol consumption was positively associated with the incidence of diabetes in Japanese lean (BMI less than or equal to 22 kg/m(2)) men.
引用
收藏
页码:323 / 331
页数:9
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