Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer

被引：26

作者：

Sakakura, K

Chikamatsu, K

Sakurai, T

Takahashi, K

Murata, T

Oriuchi, N

Furuya, N

机构：

[1] Gunma Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Maebashi, Gumma 3718511, Japan

[2] Gunma Univ, Grad Sch Med, Dept Diagnost Radiol & Nucl Med, Maebashi, Gumma 3718511, Japan

来源：

ORAL ONCOLOGY | 2005年 / 41卷 / 01期

关键词：

dendritic cells; NK cells; sentinel lymph nodes; oral cavity cancer;

D O I：

10.1016/j.oraloncology.2004.07.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The sentinel lymph node (SLN) is regarded as the first tumor-draining lymph node, which may be the initial site activated by tumor antigens. To clarify the immunological functions of SLNs, a total of 89 tumor-free regional lymph nodes (41 SLNs and 48 non-SLNs) were obtained from 12 patients with oral cavity cancer, and infiltration of both DCs and NK cells was determined by immunohistochemistry. S-100+ and CD1a+ DCs infiltrated significantly into SLNs compared to non-SLNs. Analysis in each of the pN0 and pN+ patients showed that all the DC markers in pN0 patients and only S-100+ in pN+ patients were significantly more abundant in SLNs. Moreover, infiltration of CD83+ DCs was less in pN+ patients than in pN0 patients. These results suggest that more significant immune responses against cancer occur in SLNs than in non-SLNs. However the progression of disease including nodal disease may cause systemic immunosuppression. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：89 / 96

页数：8

共 24 条

[1] A preliminary study on sentinel lymph node biopsy: feasibility and predictive ability in oral cavity cancer [J].