PDZ interactions and proximal tubular phosphate reabsorption

被引：26

作者：

Biber, J ^{[1
]}

Gisler, SM ^{[1
]}

Hernando, N ^{[1
]}

Wagner, CA ^{[1
]}

Murer, H ^{[1
]}

机构：

[1] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2004年 / 287卷 / 05期

关键词：

sodium-inoganic cotransport; PDZK1; Na/H exchanger regulatory factor-1; type IIa sodium-phosphate cotransporter;

D O I：

10.1152/ajprenal.00244.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

In adults, the extent of renal reabsorption of Pi and consequently the extent of urinary excretion of phosphate are to a large extent determined by the abundance of the Na-P-i cotransporter NaPi-IIa (SLC34A1). Localization of this cotransporter is restricted to the apical membrane of proximal tubular cells, and its abundance is controlled by a number of factors and pathophysiological conditions. To guarantee a proper apical localization and specific regulated endocytosis of NaPi-IIa, an orchestrated pattern of protein interactions has to be envisaged. Attempts to screen for such interacting proteins resulted in the identification of a PDZ domain containing proteins. The purpose of this review is to discuss the roles of these PDZ proteins in proximal tubular Na-P-i cotransport.

引用

页码：F871 / F875

页数：5

共 44 条

[1] Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transport
Ba, JM
Brown, D
Friedman, PA
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 285 (06) : F1233 - F1243
[2] BACIC D, IN PRESS KIDNEY INT
[3] Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities
Beck, L
Karaplis, AC
Amizuka, N
Hewson, AS
Ozawa, H
Tenenhouse, HS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) : 5372 - 5377
[4] ERM-merlin and EBP50 protein families in plasma membrane organization and function
Bretscher, A
Chambers, D
Nguyen, R
Reczek, D
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2000, 16 : 113 - +
[5] A golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression
Cheng, J
Moyer, BD
Milewski, M
Loffing, J
Ikeda, M
Mickle, JE
Cutting, GR
Li, M
Stanton, BA
Guggino, WB
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (05) : 3520 - 3529
[6] PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane
Fanning, AS
Anderson, JM
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (06) : 767 - 772
[7] PDZK1: II. An anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells
Gisler, SM
Madjdpour, C
Bacic, D
Pribanic, S
Taylor, SS
Biber, J
Murer, H
[J]. KIDNEY INTERNATIONAL, 2003, 64 (05) : 1746 - 1754
[8] PDZK1: I. A major scaffolder in brush borders of proximal tubular cells
Gisler, SM
Pribanic, S
Bacic, D
Forrer, P
Gantenbein, A
Sabourin, LA
Tsuji, A
Zhao, ZS
Manser, E
Biber, J
Murer, H
[J]. KIDNEY INTERNATIONAL, 2003, 64 (05) : 1733 - 1745
[9] Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
Gisler, SM
Stagljar, I
Traebert, M
Bacic, D
Biber, J
Murer, H
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (12) : 9206 - 9213
[10] Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif
Haggie, PM
Stanton, BA
Verkman, AS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (07) : 5494 - 5500

← 1 2 3 4 5 →