Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication

被引:181
作者
Mothé, BR
Weinfurter, J
Wang, CX
Rehrauer, W
Wilson, N
Allen, TM
Allison, DB
Watkins, DI
机构
[1] Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53715 USA
[2] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53792 USA
[3] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35294 USA
关键词
D O I
10.1128/JVI.77.4.2736-2740.2003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Several HLA alleles are associated with attenuated human immunodeficiency virus disease progression. We explored the relationship between the expression of particular major histocompatibility complex (MHC) class I alleles and viremia in simian immunodeficiency virus SIV(mac)239-infected macaques. Of the common MHC class I alleles, animals that expressed Mamu-A*01 exhibited the best control of viral replication.
引用
收藏
页码:2736 / 2740
页数:5
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