Brx Shines a Light on the Route from Hyperosmolarity to NFAT5

被引：18

作者：

Aramburu, Jose ^{[1
]}

Lopez-Rodriguez, Cristina ^{[1
]}

机构：

[1] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona 08003, Spain

来源：

SCIENCE SIGNALING | 2009年 / 2卷 / 65期

关键词：

ENHANCER-BINDING PROTEIN; HYPERTONIC STRESS-RESPONSE; TRANSCRIPTION FACTOR; OSMOTIC-STRESS; HIGH NACL; ACTIVATION; CELLS; MICE; P38; TONEBP/OREBP;

D O I：

10.1126/scisignal.265pe20

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear factor of activated T cells 5 (NFAT5) is a member of the Rel family of transcription factors and is an essential inducer of osmoprotective gene products in mammalian cells. Its activation by hypertonicity requires p38 mitogen-activated protein kinase (MAPK) signaling and other pathways. A study now elucidates a signaling cascade regulated by the guanine nucleotide exchange factor Brx that leads to the activation of p38 alpha MAPK and the induction of nfat5 messenger RNA in response to osmotic stress in lymphocytes and renal medullary cells. Brx-deficient lymphocytes showed impaired responses to hypertonicity, and brx(+/-) mice exhibited immune defects similar to those of nfat5-deficient mice. These findings support a major role for Brx in regulating the osmoprotective function of NFAT5 in different cell types.

引用

页数：3

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