The Radical Scavenger Edaravone Improves Neurologic Function and Perihematomal Glucose Metabolism after Acute Intracerebral Hemorrhage

被引：42

作者：

Shang, Hanbing ^{[1
]}

Cui, Derong ^{[2
]}

Yang, Dehua ^{[3
,4
]}

Liang, Sheng ^{[5
,6
]}

Zhang, Weifeng ^{[1
]}

Zhao, Weiguo ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Neurosurg, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 6, Dept Anesthesiol, Shanghai 200025, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Nucl Med, Shanghai 200025, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Micro PET CT Res Ctr, Shanghai 200025, Peoples R China

来源：

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2015年 / 24卷 / 01期

关键词：

Intracerebral hemorrhage; edaravonecerebral metabolism; apoptosis; positron emission tomography/computed; tomography; TRAUMATIC BRAIN-INJURY; ANEURYSMAL SUBARACHNOID HEMORRHAGE; ACUTE CEREBRAL INFARCTION; CELL-DEATH; WHOLE-BLOOD; RAT MODEL; ISCHEMIA; MICRODIALYSIS; EDEMA; PLASMA;

D O I：

10.1016/j.jstrokecerebrovasdis.2014.08.021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oxidative injury caused by reactive oxygen species plays an important role in the progression of intracerebral hemorrhage (ICH)-induced secondary brain injury. Previous studies have demonstrated that the free radical scavenger edaravone may prevent neuronal injury and brain edema after ICH. However, the influence of edaravone on cerebral metabolism in the early stages after ICH and the underlying mechanism have not been fully investigated. In the present study, we investigated the effect of edaravone on perihematomal glucose metabolism using F-18-fluorordeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). Additionally, the neurologic deficits, brain edemas, and cell death that followed ICH were quantitatively analyzed. After blood infusion, the rats treated with edaravone showed significant improvement in both forelimb placing and corner turn tests compared with those treated with vehicle. Moreover, the brain water content of the edaravone-treated group was significantly decreased compared with that of the vehicle group on day 3 after ICH. PET/CT images of ICH rats exhibited obvious decreases in FDG standardized uptake values in perihematomal region on day 3, and the lesion-to-normal ratio of the edaravone-treated ICH rats was significantly increased compared with that of the control rats. Calculation of the brain injury volumes from the PET/CT images revealed that the volumes of the blood-induced injuries were significantly smaller in the edaravone group compared with the vehicle group. Terminal Deoxynucleotidyl Transferasemediated dUTP Nick End Labeling assays performed 3 days after ICH revealed that the numbers of apoptotic cells in perihematomal region of edaravone-treated ICH rats were decreased relative to the vehicle group. Thus, the present study demonstrates that edaravone has scavenging properties that attenuate neurologic behavioral deficits and brain edema in the early period of ICH. Additionally, edaravone may improve cerebral metabolism around the hematoma by attenuating apoptotic cell death after ICH.

引用

页码：215 / 222

页数：8

共 54 条

[1] STRONG ATTENUATION OF ISCHEMIC AND POSTISCHEMIC BRAIN EDEMA IN RATS BY A NOVEL FREE-RADICAL SCAVENGER [J].