Isoxazole-based derivatives from Baylis-Hillman chemistry: Assessment of preliminary hypolipidemic activity

被引:33
作者
Patra, A
Batra, S
Bhaduri, AP
Khanna, A
Chander, R
Dikshit, M
机构
[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Biochem, Lucknow 226001, Uttar Pradesh, India
[3] Cent Drug Res Inst, Div Pharmacol, Lucknow 226001, Uttar Pradesh, India
关键词
D O I
10.1016/S0968-0896(03)00105-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthesis of isoxazole-based derivatives utilizing Baylis-Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2269 / 2276
页数:8
相关论文
共 46 条
[1]   Correlation between pKa and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction:: Discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope [J].
Aggarwal, VK ;
Emme, I ;
Fulford, SY .
JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (03) :692-700
[2]   Rate acceleration of the Baylis-Hillman reaction in polar solvents (water and formamide). Dominant role of hydrogen bonding, not hydrophobic effects, is implicated [J].
Aggarwal, VK ;
Dean, DK ;
Mereu, A ;
Williams, R .
JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (02) :510-514
[3]   Piperonal as electrophile in the Baylis-Hillman reaction.: A synthesis of hydroxy-β-piperonyl-γ-butyrolactone derivative [J].
Almeida, WP ;
Coelho, F .
TETRAHEDRON LETTERS, 1998, 39 (47) :8609-8612
[4]   Elaboration of a Baylis-Hillman adduct to (-)-acaterin and its diastereomer through ring closing metathesis [J].
Anand, RV ;
Baktharaman, S ;
Singh, VK .
TETRAHEDRON LETTERS, 2002, 43 (31) :5393-5395
[5]  
[Anonymous], WORLD HLTH REP
[6]   Applications of Baylis-Hillman chemistry:: one-pot convenient synthesis of functionalized (1H)-quinol-2-ones and quinolines [J].
Basavaiah, D ;
Reddy, RM ;
Kumaragurubaran, N ;
Sharada, DS .
TETRAHEDRON, 2002, 58 (19) :3693-3697
[7]   The Baylis-Hillman reaction: A novel carbon-carbon bond forming reaction [J].
Basavaiah, D ;
Rao, PD ;
Hyma, RS .
TETRAHEDRON, 1996, 52 (24) :8001-8062
[8]   One-pot facile conversion of the acetates of Baylis-Hillman adducts into substituted fused pyrimidones in aqueous media [J].
Basavaiah, D ;
Satyanarayana, T .
TETRAHEDRON LETTERS, 2002, 43 (24) :4301-4303
[9]  
BASAVAIAH D, 2003, CHEM REV
[10]   Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents [J].
Batra, S ;
Srinivasan, T ;
Rastogi, SK ;
Kundu, B ;
Patra, A ;
Bhaduri, AP ;
Dixit, M .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (15) :1905-1908