Stimulus onset quenches neural variability: a widespread cortical phenomenon

被引：702

作者：

Churchland, Mark M. ^{[1
,2
]}

Yu, Byron M. ^{[1
,2
,3
]}

Cunningham, John P. ^{[1
]}

Sugrue, Leo P. ^{[2
,4
]}

Cohen, Marlene R. ^{[2
,4
]}

Corrado, Greg S. ^{[2
,4
]}

Newsome, William T. ^{[2
,4
,5
]}

Clark, Andrew M. ^{[6
,7
]}

Hosseini, Paymon ^{[6
,7
]}

Scott, Benjamin B. ^{[6
,7
]}

Bradley, David C. ^{[6
,7
]}

Smith, Matthew A. ^{[8
,9
]}

Kohn, Adam ^{[10
,11
]}

Movshon, J. Anthony ^{[11
]}

Armstrong, Katherine M. ^{[2
,5
]}

Moore, Tirin ^{[2
,5
]}

Chang, Steve W. ^{[12
]}

Snyder, Lawrence H. ^{[12
]}

Lisberger, Stephen G. ^{[13
,14
]}

Priebe, Nicholas J. ^{[15
]}

Finn, Ian M. ^{[16
]}

Ferster, David ^{[16
]}

Ryu, Stephen I. ^{[1
,17
]}

Santhanam, Gopal ^{[1
]}

Sahani, Maneesh ^{[3
]}

Shenoy, Krishna V. ^{[1
,2
,18
]}

机构：

[1] Stanford Univ, Dept Elect Engn, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Neurosci Program, Sch Med, Stanford, CA 94305 USA

[3] UCL, Gatsby Computat Neurosci Unit, London, England

[4] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Neurobiol, Sch Med, Stanford, CA 94305 USA

[6] Univ Chicago, Dept Psychol, Chicago, IL 60637 USA

[7] Univ Chicago, Comm Computat Neurosci, Chicago, IL 60637 USA

[8] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA USA

[9] Univ Pittsburgh, Ctr Neural Basis Cognit, Pittsburgh, PA USA

[10] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10467 USA

[11] NYU, Ctr Neural Sci, New York, NY 10003 USA

[12] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA

[13] Univ Calif San Francisco, Howard Hughes Med Inst, WM Keck Fdn, Ctr Integrat Neurosci, San Francisco, CA 94143 USA

[14] Univ Calif San Francisco, Dept Physiol, San Francisco, CA USA

[15] Univ Texas Austin, Neurobiol Sect, Sch Biol Sci, Austin, TX 78712 USA

[16] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

[17] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA

[18] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

TO-TRIAL VARIABILITY; RESPONSE VARIABILITY; AREA MT; NEURONS; DIRECTION; CORTEX; MODULATION; DYNAMICS; INFORMATION; MICROSTIMULATION;

D O I：

10.1038/nn.2501

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neural responses are typically characterized by computing the mean firing rate, but response variability can exist across trials. Many studies have examined the effect of a stimulus on the mean response, but few have examined the effect on response variability. We measured neural variability in 13 extracellularly recorded datasets and one intracellularly recorded dataset from seven areas spanning the four cortical lobes in monkeys and cats. In every case, stimulus onset caused a decline in neural variability. This occurred even when the stimulus produced little change in mean firing rate. The variability decline was observed in membrane potential recordings, in the spiking of individual neurons and in correlated spiking variability measured with implanted 96-electrode arrays. The variability decline was observed for all stimuli tested, regardless of whether the animal was awake, behaving or anaesthetized. This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input.

引用

页码：369 / U25

页数：12

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