Sex dimorphism in gray/white matter volume and diffusion tensor during normal aging

被引：33

作者：

Abe, Osamu ^{[1
]}

Yamasue, Hidenori ^{[2
]}

Yamada, Haruyasu ^{[3
]}

Masutani, Yoshitaka

Kabasawa, Hiroyuki ^{[4
]}

Sasaki, Hiroki

Takei, Kunio ^{[2
]}

Suga, Motomu ^{[2
]}

Kasai, Kiyoto ^{[2
]}

Aoki, Shigeki ^{[5
]}

Ohtomo, Kuni

机构：

[1] Univ Tokyo, Dept Radiol, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo 1138655, Japan

[3] Teikyo Univ, Chiba Med Ctr, Dept Radiol, Chiba, Japan

[4] GE Yokogawa Med Syst, MR Appl Sci Lab Japan, Tokyo, Japan

[5] Juntendo Univ, Dept Radiol, Grad Sch Med, Tokyo, Japan

来源：

NMR IN BIOMEDICINE | 2010年 / 23卷 / 05期

基金：

日本学术振兴会;

关键词：

aging; central nervous system; diffusion tensor imaging; magnetic resonance imaging; sex; voxel-based morphometry; AGE-RELATED-CHANGES; HORMONE REPLACEMENT THERAPY; HEALTHY-YOUNG ADULTS; WHITE-MATTER; HUMAN BRAIN; CEREBRAL-CORTEX; CORTICAL THICKNESS; GENDER-DIFFERENCES; GRAY-MATTER; MRI;

D O I：

10.1002/nbm.1479

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The purpose of this study is to elucidate sex differences in global and regional gray/white matter volume, mean diffusivity (MD), and fractional anisotropy (FA) during normal aging using voxel-based analysis. We studied 245 healthy right-handed subjects with a wide range of ages (115 women, 22-70 years; 130 men, 21-71 years). Regarding global effects, inclusion of a quadratic age term improved the fit to data for white matter fraction and MD, but not for global gray matter volume/fraction or FA. Regarding regional effects, we found anterior-dominant volume loss, FA decrease predominantly in the anterior white matter, and MD increase predominantly in perisylvian regions and periventricular white matter against age for both sexes. Compared with women, we found a steeper FA decline for men in the right inferior fronto-temporal areas, extending to the anterior cingulate cortex, and an accelerated MD increase for men in the bilateral frontal, temporal, and parietal areas. There was no area in which interaction of sex with age was significant for regional volume, or in which a steeper FA decline or accelerated MD increase for women was significant. Our results provide strong evidence of sex dimorphism in global and focal diffusion characteristics during normal aging. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：446 / 458

页数：13

共 70 条

[1] Amyotrophic lateral sclerosis: diffusion tensor tractography and voxel-based analysis [J].

Abe, O ;

Yamada, H ;

Masutani, Y ;

Aoki, S ;

Kunimatsu, A ;

Yamasue, H ;

Fukuda, R ;

Kasai, K ;

Hayashi, N ;

Masumoto, T ;

Mori, H ;

Soma, T ;

Ohtomo, K .

NMR IN BIOMEDICINE, 2004, 17 (06) :411-416

[2] Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis [J].

Abe, O ;

Aoki, S ;

Hayashi, N ;

Yamada, H ;

Kunimatsu, A ;

Mori, H ;

Yoshikawa, T ;

Okubo, T ;

Ohtomo, K .

NEUROBIOLOGY OF AGING, 2002, 23 (03) :433-441

[3] Aging in the CNS: Comparison of gray/white matter volume and diffusion tensor data [J].

Abe, Osamu ;

Yamasue, Hidenori ;

Aoki, Shigeki ;

Suga, Motomu ;

Yamada, Haruyasu ;

Kasai, Kiyoto ;

Masutani, Yoshitaka ;

Kato, Nobuyuki ;

Kato, Nobumasa ;

Ohtomo, Kuni .

NEUROBIOLOGY OF AGING, 2008, 29 (01) :102-116

[4] Normal neuroanatomical variation due to age: The major lobes and a parcellation of the temporal region [J].

Allen, JS ;

Bruss, J ;

Brown, CK ;

Damasio, H .

NEUROBIOLOGY OF AGING, 2005, 26 (09) :1245-1260

[5] Methods for studying the aging brain: Volumetric analyses versus VBM [J].

Allen, JS ;

Bruss, J ;

Brown, CK ;

Damasio, H .

NEUROBIOLOGY OF AGING, 2005, 26 (09) :1275-1278

[6] Unified segmentation [J].

Ashburner, J ;

Friston, KJ .

NEUROIMAGE, 2005, 26 (03) :839-851

[7] Age-related changes in frontal and temporal lobe volumes in men - A magnetic resonance imaging study [J].

Bartzokis, G ;

Beckson, M ;

Lu, PH ;

Nuechterlein, KH ;

Edwards, N ;

Mintz, J .

ARCHIVES OF GENERAL PSYCHIATRY, 2001, 58 (05) :461-465

[8] Influence of aging on brain gray and white matter changes assessed by conventional, MT, and DT MRI [J].

Benedetti, B ;

Charil, A ;

Rovaris, M ;

Judica, E ;

Valsasina, P ;

Sormani, MP ;

Filippi, M .

NEUROLOGY, 2006, 66 (04) :535-539

[9] Diffusion anisotropy in subcortical white matter and cortical gray matter: Changes with aging and the role of CSF-suppression [J].

Bhagat, YA ;

Beaulieu, C .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2004, 20 (02) :216-227

[10] Sex differences in regional gray matter in healthy individuals aged 44-48 years: A voxel-based morphometric study [J].

Chen, Xiaohua ;

Sachdev, Perminder S. ;

Wen, Wei ;

Anstey, Kaarin J. .

NEUROIMAGE, 2007, 36 (03) :691-699

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