Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans

被引：5

作者：

Knight, J ^{[1
]}

Gardner, GTB ^{[1
]}

Clark, AJL ^{[1
]}

Caulfield, MJ ^{[1
]}

机构：

[1] St Bartholomews & Royal London Sch Med & Dent, London, England

来源：

JOURNAL OF HUMAN HYPERTENSION | 2000年 / 14卷 / 06期

关键词：

essential hypertension; linkage; chromosome; 17; comparative mapping; African Caribbean;

D O I：

10.1038/sj.jhh.1001025

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Essential hypertension is a major risk factor for cardiovascular disease in humans, and originates from both genetic and environmental factors. Data from animal and more recently human studies have indicated the presence of a gene influencing blood pressure on human chromosome 17. This study tested for linkage of markers located on chromosome 17q to essential hypertension in African Caribbean hypertensive families, No support of linkage was found between the markers studied and hypertension, however only genes of a lamda sib value of less than 1.8 could be excluded.

引用

页码：385 / 387

页数：3

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