DNA adenine methylation and bacterial pathogenesis

被引：86

作者：

Heusipp, Gerhard ^{[1
]}

Faelker, Stefan ^{[1
]}

Schmidt, M. Alexander ^{[1
]}

机构：

[1] Univ Klinikum Munster, Inst Infektiol, Zentrum Mol Biol Entzundung ZMBE, D-48149 Munster, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2007年 / 297卷 / 01期

关键词：

DNA adenine methylation; virulence gene expression; regulation;

D O I：

10.1016/j.ijmm.2006.10.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Methylation of DNA by the DNA adenine methyltransferase (Dam) provides an epigenetic signal that influences and regulates numerous physiological processes in the bacterial cell including chromosome replication, mismatch repair, transposition, and transcription. A growing number of reports describe a role for DNA adenine methylation in regulating the expression of various bacterial genes related to virulence in diverse pathogens, suggesting that DNA methylation may be a widespread and versatile regulator of virulence gene expression. Here, we summarize the current knowledge about the influence of DNA methylation on virulence functions and discuss perspectives for future research. (c) 2006 Elsevier GmbH. All rights reserved.

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页码：1 / 7

页数：7

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