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Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort
被引:40
作者:
Chandalia, Manisha
Grundy, Scott M.
Adams-Huet, Beverley
Abate, Nicola
机构:
[1] Univ Texas, SW Med Ctr, Div Endocrinol & Metab, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Ctr Human Nutr, Dept Med, Dallas, TX 75390 USA
[3] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
[4] Univ Texas, SW Med Ctr, Donald W Reynolds Cardiovasc Clin Res Ctr, Dallas, TX 75390 USA
[5] Univ Texas, SW Med Ctr, Dept Clin Sci, Dallas, TX 75216 USA
[6] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75216 USA
关键词:
type;
2;
diabetes;
insulin resistance;
ethnicity;
ENPP1;
PC-1;
D O I:
10.1016/j.jdiacomp.2006.11.003
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Genetic susceptibility modulates the impact of obesity on the risk for type 2 diabetes. One candidate gene predisposing to type 2 diabetes is ENPP1/PC1. A common polymorphism in this protein, K121Q, is associated with insulin resistance and increased susceptibility to type 2 diabetes in Caucasian, Afro-Caribbean, and South Asian populations. The goal of this study was to evaluate differences in the prevalence of the ENPP1 121Q variant in the Caucasian, African-American, and Hispanic populations in Dallas county and to establish a population-based estimate of gene variant prevalence for future investigations. We also evaluated the association between the ENPP1 121Q variant and diabetes. The Dallas Heart Study (DHS) is a multiethnic probability-based sample of the Dallas county population in which African-Americans were systematically oversampled so that the final sample was 50% African-Americans. We performed ENPP1/PC1 genotyping in 1038 non-Hispanic Whites (544 women, 494 men), 1815 African-Americans (1052 women and 763 men), and 597 Hispanics (347 women, 250 men). The frequency of ENPP1/PC1 K121Q was higher in both African-Americans (78.5%) and Hispanics (21.9%) than in the non-Hispanic White group (13.2%). The former two groups also have a higher prevalence of type 2 diabetes (African-Americans, 14.1%, and Hispanics, 11.7%) compared to non-Hispanic Whites (6.8%). Logistic regression analysis revealed significant interactions between the ENPP1 genotype, age, and body mass index within each ethnic group. After adjustment for these variables and their interactions, ENPP1 Q allele predicted diabetes when a recessive model was tested. Ethnic differences in ENPP1 121Q allele frequency may contribute to the increased susceptibility to type 2 diabetes observed in US minority groups. (c) 2007 Elsevier Inc. All rights reserved.
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页码:143 / 148
页数:6
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