Conformational control of HCl co-transporter:: imidazole functionalised isophthalamide vs. 2,6-dicarboxamidopyridine

被引：69

作者：

Gale, Philip A. ^{[1
]}

Garric, Joachim

Light, Mark E.

McNally, Beth A.

Smith, Bradley D.

机构：

[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

[2] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 17期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1039/b703259e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Replacement of the central isophthalamide core in a synthetic HCl receptor, with a 2,6-dicarboxamidopyridine, leads to a more preorganised molecular structure that exhibits higher chloride affinity and membrane transport flux.

引用

页码：1736 / 1738

页数：3

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