RAGE (receptor for advanced glycation end products): a central player in the inflammatory response

被引：236

作者：

Chavakis, T ^{[1
]}

Bierhaus, A ^{[1
]}

Nawroth, PP ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Internal Med 1, D-69120 Heidelberg, Germany

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 13期

关键词：

innate immunity; glycation; adhesion; leukocyte; integrin;

D O I：

10.1016/j.micinf.2004.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present review focuses on the role of RAGE, the "receptor for advanced glycation end products", in the inflammatory response. RAGE is a multiligand receptor that propagates cellular dysfunction in several inflammatory disorders, in tumors and in diabetes. RAGE is expressed at low levels in normal tissues, but becomes upregulated at sites where its ligands accumulate. RAGE may play a dual role in the inflammatory response: (i) interaction of RAGE on leukocytes or endothelial cells (ECs) with its ligands results in cellular activation involving the transcription factor NF-kappaB; (ii) on the other hand, RAGE on ECs may function as an adhesive receptor that directly interacts with leukocyte B2-integrins, thereby directly being involved in inflammatory cell recruitment. These different aspects are discussed in the present review. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：1219 / 1225

页数：7

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