Time to menopause in relation to PBBs, PCBs, and smoking

被引:27
作者
Blanck, HM
Marcus, M
Tolbert, PE
Schuch, C
Rubin, C
Henderson, AK
Zhang, RH
Hertzberg, VS
机构
[1] CDCP, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Nutr & Phys Act, Chron Dis Nutr Branch, Atlanta, GA 30341 USA
[2] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA
[3] Emory Univ, Rollins Sch Publ Hlth, Dept Environm & Occupat Hlth, Atlanta, GA USA
[4] CDCP, Natl Ctr Environm Hlth, Atlanta, GA USA
[5] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat, Atlanta, GA USA
关键词
menopause; Michigan; polybrominated biphenyls; polychlorinated biphenyls; smoking;
D O I
10.1016/j.maturitas.2003.10.011
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objectives: Because halogenated biphenyl exposure is suspected to disrupt endocrine function, we assessed time to menopause in women aged 24 years and older who were exposed orally to polybrominated biphenyls (PBBs) and polychlorinated biphenyls (PCBs) (n = 874). We also examined smoking in relation to menopause. Methods: To define menopausal status, women were interviewed in 1997 and asked whether they had had any menstrual periods in the previous year, why their menstrual periods had stopped (e.g. surgery), and age at their last menstrual period. Serum PBB and PCB taken at enrollment (1976-1978) into the Michigan PBB registry was used as the measure of halogenated biphenyl exposure. Women whose menopause occurred before their PBB exposure were excluded. Proportional hazard modeling was used to analyze the "risk" for menopause in relation to exposure. Premenopausal women contributed person-time until their interview date, at which time they were censored. Results: We did not find an association between either PBB or PCB exposure and time to menopause. Women who were current smokers had a shorter time to menopause than never smokers (menopause ratio 2.02, 95% C.I. 1.21-3.37). Time to menopause was shortest among women who reported started smoking when they were < 18 years of age, smoked at least 20 cigarettes per day, or had at least 10 pack-years of smoking.
引用
收藏
页码:97 / 106
页数:10
相关论文
共 45 条
[1]  
Allen J R, 1979, Ann N Y Acad Sci, V320, P419
[2]  
Allison PD., 2010, SURVIVAL ANAL USING
[3]   VARIATIONS IN THE REPORTING OF MENSTRUAL HISTORIES [J].
BEAN, JA ;
LEEPER, JD ;
WALLACE, RB ;
SHERMAN, BM ;
JAGGER, H .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1979, 109 (02) :181-185
[4]  
Bromberger JT, 1997, AM J EPIDEMIOL, V145, P124
[5]   INTER-LABORATORY COMPARISON FOR RESULTS OF ANALYSES FOR POLYBROMINATED BIPHENYLS IN HUMAN-SERUM [J].
BURSE, VW ;
NEEDHAM, LL ;
LIDDLE, JA ;
BAYSE, DD ;
PRICE, HA .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1980, 4 (01) :22-26
[6]  
BURSE VW, 1989, J ASSOC OFF ANA CHEM, V72, P649
[7]   MICHIGANS PBB INCIDENT - CHEMICAL MIX-UP LEADS TO DISASTER [J].
CARTER, LJ .
SCIENCE, 1976, 192 (4236) :240-243
[8]   A validation study on status and age of natural menopause reported in the E3N cohort [J].
Clavel-Chapelon, F ;
Dormoy-Mortier, N .
MATURITAS, 1998, 29 (02) :99-103
[9]   REPRODUCIBILITY AND VALIDITY OF SELF-REPORTED MENOPAUSAL STATUS IN A PROSPECTIVE COHORT STUDY [J].
COLDITZ, GA ;
STAMPFER, MJ ;
WILLETT, WC ;
STASON, WB ;
ROSNER, B ;
HENNEKENS, CH ;
SPEIZER, FE .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1987, 126 (02) :319-325
[10]   Measures of menopausal status in relation to demographic, reproductive, and behavioral characteristics in a population-based study of women aged 35-49 years [J].
Cooper, GS ;
Baird, DD ;
Darden, FR .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2001, 153 (12) :1159-1165