X-changing information on X inactivation

被引：37

作者：

Barakat, Tahsin Stefan ^{[1
]}

Jonkers, Iris ^{[1
]}

Monkhorst, Kim ^{[1
]}

Gribnau, Joost ^{[1
]}

机构：

[1] Erasmus MC, Dept Reprod & Dev, NL-3000 CA Rotterdam, Netherlands

来源：

EXPERIMENTAL CELL RESEARCH | 2010年 / 316卷 / 05期

关键词：

X chromosome inactivation; XCI; Stochastic; Xist; Tsix; Rnf12; CHROMOSOME INACTIVATION; XIST PROMOTER; INTERGENIC TRANSCRIPTION; ANTISENSE TRANSCRIPTION; DOSAGE COMPENSATION; TSIX TRANSCRIPTION; COUNTING PROCESS; GENE; CHOICE; CELLS;

D O I：

10.1016/j.yexcr.2010.01.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In female somatic cells of mammalian species one X chromosome is inactivated to ensure dosage equality of X-encoded genes between females and males, during development and adulthood X chromosome inactivation (XCI) involves various epigenetic mechanisms, Including RNA mediated gene silencing in cis, DNA methylation, and changes in chromatin modifications and composition XCI therefore provides an attractive paradigm to study epigenetic gene regulation in a more general context. The XCI process starts with counting of the number of X chromosomes present in a nucleus, and initiation of XCI follows if this number exceeds one per diploid genome Recently, X-encoded RNF12 has been identified as a close-dependent activator of XCL. In addition, other factors, including the pluripotency factors OCT4, SOX2 and Nanog, have been implicated to play a role in suppression of initiation of XCl. In this review, we highlight and explain these new and old findings in the context of a stochastic model for X chromosome counting and XCl initiation (c) 2010 Elsevier Inc All rights reserved

引用

页码：679 / 687

页数：9

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