Synthesis and cytotoxicity of gossypol related compounds

被引:108
作者
Dao, VT
Gaspard, C
Mayer, M
Werner, GH
Nguyen, SN
Michelot, RJ [1 ]
机构
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
[2] Univ Ho Chi Minh City, Dept Organ Chem, Ho Chi Minh City, Vietnam
关键词
gossypol; gossypolone; Schiff's bases; reduced gossypol; oxygen radical scavengers; cytotoxicity;
D O I
10.1016/S0223-5234(00)00165-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Gossypol, gossypolone, reduced gossypol and new Schiff's bases of racemic gossypol and gossypolone were extracted or synthesized. Their cytotoxic activities on KB human cancer cells were determined. Gossypolone and the ethylamine derivative of gossypolone were the most active compounds (IC50 in the micromolar range in both cases). The cytotoxicity of gossypol and gossypolone was increased when the tests were performed in the absence of serum and decreased when catalase as well as mannitol were added to the culture medium. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:805 / 813
页数:9
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