In vivo visualization of macrophage infiltration and activity in inflammation using magnetic resonance imaging

被引：56

作者：

Beckmann, Nicolau ^{[1
]}

Cannet, Catherine ^{[1
]}

Babin, Anna Louise ^{[1
,2
,3
]}

Ble, Francois-Xavier ^{[2
,4
]}

Zurbruegg, Stefan ^{[1
]}

Kneuer, Rainer ^{[1
]}

Dousset, Vincent ^{[5
]}

机构：

[1] Novartis Inst BioMed Res, Global Imaging Grp Forum 1, CH-4056 Basel, Switzerland

[2] Novartis Inst BioMed Res, Dept Resp Dis, CH-4056 Basel, Switzerland

[3] Kings Coll London, Sackler Inst Pulm Pharmacol, London SE1 1UL, England

[4] Toronto Ctr Phenogen, Mouse Imaging Ctr, Toronto, ON M5T 3H7, Canada

[5] Univ Bordeaux 2, CHU Bordeaux, EA Neurobiol Myelin Dis Lab 2966, F-33076 Bordeaux, France

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2009年 / 1卷 / 03期

关键词：

SUPERPARAMAGNETIC IRON-OXIDE; BLOOD-BRAIN-BARRIER; MR CONTRAST AGENTS; CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PERIPHERAL BENZODIAZEPINE-RECEPTOR; CAROTID ATHEROSCLEROTIC PLAQUE; ANTIGEN-INDUCED ARTHRITIS; FOCAL CEREBRAL-ISCHEMIA; LYMPH-NODE METASTASES;

D O I：

10.1002/wnan.16

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Because macrophages play a key role on host defense, visualization of the migration of these cells is of high relevance for both diagnostic purposes and the evaluation of therapeutic interventions. The present article addresses the use of iron oxide and gadolinium-based particles for the noninvasive in vivo detection of macrophage infiltration into inflamed areas by magnetic resonance imaging (MRI). A general introduction on the functions and general characteristics of macrophages is followed by a discussion of some of the agents and acquisition schemes currently used to track the cells in vivo. Attention is then devoted to preclinical and clinical applications in the following disease areas: atherosclerosis and myocardial infarction, stroke, multiple sclerosis, rheumatoid arthritis, and kidney transplantation. (C) 2009 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2009 1 272-298

引用

页码：272 / 298

页数：27

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