Nitrile oxides in medicinal chemistry .6. Enzymatic resolution of a set of bicyclic Delta(2)-isoxazolines.

被引：10

作者：

DeAmici, M ^{[1
]}

DeMicheli, C ^{[1
]}

Carrea, G ^{[1
]}

Riva, S ^{[1
]}

机构：

[1] CNR, IST CHIM ORMONI, I-20131 MILAN, ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 03期

关键词：

D O I：

10.1016/0957-4166(96)00075-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chymotrypsin selectively catalyzed the hydrolysis of a series of 3-ethoxycarbonyl-Delta(2)-isoxazolines 1-4, whereas lipase from Pseudomonas cepacia (lipase PS) was remarkably selective in hydrolysing the corresponding 3-hydroxymethyl-Delta(2)-isoxazoline butyrates (5-8). The enantio-preference of chymotrypsin for the first set of compounds is the same as that observed for the lipase PS-cataiyzed hydrolysis of the other series of substrates. The hydrolytic activity of lipase PS for compounds 5-8 was considerably higher than that shown by chymotrypsin for substrates 1-4. (C) 1996 Elsevier Science Ltd

引用

页码：787 / 796

页数：10

共 20 条

[1]

ANNUNZIATA R, 1989, GAZZ CHIM ITAL, V119, P253

[2] METAL-HYDRIDE REDUCTION OF ISOXAZOLINE-3-CARBOXYLATE ESTERS [J].